- Ajax vs Union Berlin
- Juventus vs Nantes
- Shakhtar Donetsk vs Rennes
- Leverkusen vs AS Monaco
Leg 2: Jumat, 23 Februari 2023
- PSV vs Sevilla
- Nantes vs Juventus
- Midtyjlland vs Sporting
- Union Berlin vs Ajax
- AS Monaco vs Leverkusen